Projects related to 6-2018-4546

Results Found (21)
Technology NameBriefcaseLead Researcher
  Category LifeSciences and BioTechnology    Keywords Natural compounds, Synthetic compounds, Neurodegenerative disorders Current development stage For Pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is ...
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Tsvelikhovsky Dmitry
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
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Ben-Sasson Shmuel
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
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Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
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Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Background Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ...
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Dzikowski Ron
  Additional information will be provided upon request
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Domb Abraham
Category LifeSciences and BioTechnology    Keywords Natural compounds, Synthetic compounds, Neurodegenerative disorders Current development stage For Pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is ...
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Tsvelikhovsky Dmitry
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Category LifeSciences and BioTechnology    Keywords congestive heart failure, atrial fibrillation, cardiac steroids Current development stage For Pharmaceutical development: TRL4 - PoC&Safety of candidate device or system is ...
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Lichtstein David
  Category LifeSciences and Biotechnology    Keywords cancer, chemotherapy, prodrug Current development stage For Pharmaceutical development: TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models Choose ...
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Gibson Dan
Our Innovation   The finding by HUJI researchers uncovers a novel structure of an outer mitochondrial membrane [Fe-S] protein (mitoNEET) determined by X-ray crystallography (Fig 1)  MitoNEET is an outer mitochondrial membrane protein that ...
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Nechushtai Rachel
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
Yousef Najajreh, Al Quds University   Background A growing number of peoples worldwide are suffering from the health consequences of obesity. As for today, Only one drug is currently approved for long-treatment of obesity-the lipase ...
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Berry Elliot
Prof. Yaron Ilan, Department of Human Nutrition and Metabolism and Liver Unit Hadassah Hospital Background To date, there is no effective treatment of liver diseases with the related Hepatic-Encephalopathy symptoms. It is established that ...
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Avraham Yosefa
  Categories Small molecules, anti-inflammatory treatment Development Stage In-vivo proof of concept Patent Status Patent application filed Market Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ...
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Weinstock-Rosin Marta
  Background Primary human hepatocytes are isolated from organs rejected from transplantation. Cells are expensive, show massive batch-to-batch variability and fail to proliferate in culture. Hepatocytes are routinely used by the pharmaceutical ...
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Nahmias Yaakov
Background Hyperlipidemia is a widespread condition that affects as many as one-third of adults and an increasing number of children in developed countries. Its pathogenesis mechanisms are only partly understood. The small non-coding microRNAs ...
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Soreq Hermona
  Background Non-alcoholic fatty liver disease (NAFLD) and associated diseases Non-alcoholic steatohepatitis (NASH), Cirrhosis, and Hepatocellular carcinoma (HCC) cost the US economy an estimated at $103 billion per year. Lipotoxicity is a major ...
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Tirosh Oren
BackgroundAccording to the World Health Organization approximately 422 million people currently suffer from diabetes. Type-I diabetes patients are characterized by their pancreas β-cells dysfunction and thereby absence of insulin secretion. ...
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Willner Itamar