Projects related to 6-2018-5675

Results Found (23)
Technology NameBriefcaseLead Researcher
Our Innovation   The finding by HUJI researchers uncovers a novel structure of an outer mitochondrial membrane [Fe-S] protein (mitoNEET) determined by X-ray crystallography (Fig 1)  MitoNEET is an outer mitochondrial membrane protein that ...
More
Nechushtai Rachel
Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...
More
Tirosh Oren
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
More
Gertler Arieh
Yousef Najajreh, Al Quds University   Background A growing number of peoples worldwide are suffering from the health consequences of obesity. As for today, Only one drug is currently approved for long-treatment of obesity-the lipase ...
More
Avraham Yosefa
Prof. Yaron Ilan, Department of Human Nutrition and Metabolism and Liver Unit Hadassah Hospital Background To date, there is no effective treatment of liver diseases with the related Hepatic-Encephalopathy symptoms. It is established that ...
More
Avraham Yosefa
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
More
Ben-Sasson Shmuel
  Categories Small molecules, anti-inflammatory treatment Development Stage In-vivo proof of concept Patent Status Patent application filed Market Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ...
More
Weinstock-Rosin Marta
Category LifeSciences and BioTechnology      Application Primary human hepatocytes are isolated from organs rejected from transplantation. Cells are expensive, show massive batch-to-batch variability and fail to proliferate in culture. ...
More
Nahmias Yaakov
  Category Life Sciences and Biotechnology    Keywords Liver, RNA, miRNA Current development stage TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal modelvvvid demonstrated in  defined animal ...
More
Soreq Hermona
  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...
More
Tsvelikhovsky Dmitry
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
More
Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
More
Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
More
Reich Reuven
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
More
Ben-Sasson Shmuel
  Categories: Life sciences & Biotechnology Technology Keywords: Muscular dystrophy, nonsense mutation, Duchenne, Becker, cystic fibrosis, genetic diseases, dystrophin   Development Stage: Proof of concept  Our Innovation A nonsense ...
More
Karni Rotem
  Additional information will be provided upon request
More
Domb Abraham
  Additional information will be provided upon request
More
Domb Abraham
Category Life Sciences and Bio Technology    Keywords Iterative Stochastic Elimination (ISE), Ligands, TLRs Current development stage TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro ...
More
Goldblum Amiram
Background Age Related Macular Degeneration (AMD) is the leading cause of blindness in elderlies in the western world and an increasingly growing problem. The global AMD and diabetic retinopathy treatment market is overwhelmingly dominated by ...
More
Benny Ofra
  Background Neuro-protective drugs products of all types protect the brain and peripheral nervous system neurons from degeneration and injury by promoting neuronal survival, proliferation and differentiation. These products can be used in the ...
More
Tsvelikhovsky Dmitry
  Category Metabolic diseases Keywords Abdominal obesity, obesity Current development stage Pharmaceutical development: TRL2  Hypothesis Formulated        Collaboration Opportunity Sponsored Research with an option to License Research ...
More
Monsonego-Ornan Efrat