Projects related to 6-2017-4503

  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...

  Background DNA mutations in mitochondrial proteins/enzymes (nuclear encoded) that may lead to disease are present in approximately 1 in 8,000 individuals. Any treatment for mitochondrial diseases must be capable of targeting and crossing the ...

  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...

  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...

Background Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces Neuropeptides are potent CNS neuromodulators and have many ...

Background With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue. Attenuating deleterious age-related processes taking place in multiple organs is highly desirable. Our ...

Fills the gap between crystallography and optical imaging    Background Information about macromolecules is encoded in their shape and the way they are assembled. X-ray scattering methods are important tools for investigating the structure and ...

Background Parkinson’s Disease (PD) is a progressive neurodegenerative disease caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). As the disease progresses the number of dopaminergic neurons decreases. ...

Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293.  An essential milestone in the production ...

Category Agriculture, Food& Nutrition,  Life Science & Biotechnology Keywords Protein expression, Plant expression, biosimilar , Food, Nutrition, Functional Food, Addatives, Peptides, Protein Current development stage General list: ...

Background: Dental disorders occur when there are changes in oral hygiene, diet, medicaments or age. Our Innovation Novel dental coating that delivers therapeutics over time, as required, in response to sensed changes in acidic/basic conditions ...

  Background Current methods of tissue fixation leave much to be desired, essentially relying on technologies developed from the clothing and carpentry industries i.e. sutures, screws, and pins. Bioadhesives offer a less traumatic method of ...

Background Most active pharmaceutical ingredients (APIs) are not suitable for “passive” loading into nano-liposomes. The desired concentration in the nano-liposomes is hard to achieve. Consequently, the therapeutic efficacy in humans is not ...

Background Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces Neuropeptides are potent CNS neuromodulators and have many ...

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Background  Micro-emulsions are formed more or less spontaneously when their components are brought into contact.  They have been the only successful delivery systems for certain types of pharmaceutical compounds, particularly compounds such as ...

Background        Many of today’s leading compounds and drugs in pipeline fail to reach clinical stages due to poor oral bioavailability. In addition, Increase in oral bioavailability leads a lower inter and intra subject variability. Our ...

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Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...

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Category Agriculture Keywords Anti Biofilm, Biological Control, Controlled Release, Environmentally Friendly Current development stage General list: TRL2  Technology Concept Formulated          Collaboration Opportunity Sponsored Research ...

Category Prolonged release oral tablets    Keywords Cannabinoids, Cannabis, tablets, oral administration  Application In recent years, the medical use of cannabis and its derivatives has become widely accepted in the medical profession.  IN ...

  Background With advances in biotechnology, nasal drug delivery is increasingly becoming a more viable alternative to oral and injectable routes of administration for an increasing number of drugs, including peptides. Our Innovation Platform ...

Background Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. With high prevalence  in  ...

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Background Current preclinical and clinical data indicate that there is negligible release of drug from circulating liposomes. Once liposomes extravagate to extracellular tissue fluids, little is known of the processes determining drug release. ...