| Technology Name | Briefcase | Lead Researcher |
|---|---|---|
Categories
Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis
Development Stage
(1) In vivo tests in ... More | Gertler Arieh | |
Background
Mast cells (MCs) are a type of white blood cell active in the immune system. They are produced in the bone marrow and play a key role in the inflammatory process. Additionally, they are the primary driver of allergic reactions, ... More | Levi-Schaffer Francesca | |
Background
DNA mutations in mitochondrial proteins/enzymes (nuclear encoded) that may lead to disease are present in approximately 1 in 8,000 individuals.
Any treatment for mitochondrial diseases must be capable of targeting and crossing the ... More | Galski- Lorberboum Haya | |
Background
It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ... More | Nechushtai Rachel | |
Our Innovation
Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ... More | Ben-Sasson Shmuel | |
Background
Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces
Neuropeptides are potent CNS neuromodulators and have many ... More | Domb Abraham | |
Background
With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue.
Attenuating deleterious age-related processes taking place in multiple organs is highly desirable.
Our ... More | Keshet Eli | |
Fills the gap between crystallography and optical imaging
Background
Information about macromolecules is encoded in their shape and the way they are assembled.
X-ray scattering methods are important tools for investigating the structure and ... More | Raviv Uri | |
Background
Parkinson’s Disease (PD) is a progressive neurodegenerative disease caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). As the disease progresses the number of dopaminergic neurons decreases. ... More | Atlas Daphne | |
Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293. An essential milestone in the production ... More | Danieli Tsafi | |
Background:
Dental disorders occur when there are changes in oral hygiene, diet, medicaments or age.
Our Innovation
Novel dental coating that delivers therapeutics over time, as required, in response to sensed changes in acidic/basic conditions ... More | Friedman Michael | |
Background
Current methods of tissue fixation leave much to be desired, essentially relying on technologies developed from the clothing and carpentry industries i.e. sutures, screws, and pins. Bioadhesives offer a less traumatic method of ... More | Mandler Daniel | |
Background
Most active pharmaceutical ingredients (APIs) are not suitable for “passive” loading into nano-liposomes. The desired concentration in the nano-liposomes is hard to achieve. Consequently, the therapeutic efficacy in humans is not ... More | Goldblum Amiram | |
Additional information will be provided upon request
More | Avraham Yosefa | |
Background
Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces
Neuropeptides are potent CNS neuromodulators and have many ... More | Domb Abraham | |
Additional information will be provided upon request
More | Domb Abraham | |
Background
Micro-emulsions are formed more or less spontaneously when their components are brought into contact. They have been the only successful delivery systems for certain types of pharmaceutical compounds, particularly compounds such as ... More | Domb Abraham | |
Background
Many of today’s leading compounds and drugs in pipeline fail to reach clinical stages due to poor oral bioavailability. In addition, Increase in oral bioavailability leads a lower inter and intra subject variability.
Our ... More | Domb Abraham | |
Additional information will be provided upon request
More | Domb Abraham | |
Category
Life Sciences and Bio Technology
Keywords
Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center.
Application
Cells with multidrug resistance (MDR) due to aberrant ... More | Barenholz Yechezkel | |
Background
With advances in biotechnology, nasal drug delivery is increasingly becoming a more viable alternative to oral and injectable routes of administration for an increasing number of drugs, including peptides.
Our Innovation
Platform ... More | Touitou Elka | |
Background
Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures.
With high prevalence in ... More | Willner Itamar | |
Additional information will be provided upon request
More | Domb Abraham | |
Background
Current preclinical and clinical data indicate that there is negligible release of drug from circulating liposomes.
Once liposomes extravagate to extracellular tissue fluids, little is known of the processes determining drug release. ... More | Barenholz Yechezkel |
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