Projects related to 6-2016-4381

Results Found (42)
Technology NameBriefcaseLead Researcher
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
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Hellman Asaf
Background X-ray computed tomography (CT) instruments are among the most available, efficient and cost-effective imaging modalities in hospitals. The field of CT molecular imaging agents is emerging relying mainly on detection of gold and ...
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Blum Galia
Background Currently there are no molecules that can directly inhibit the activity of splicing factors. We created decoy oligonucleotides that directly bind and inhibit the splicing activity of splicing factors without affecting their ...
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Karni Rotem
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
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Nechushtai Rachel
  Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...
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Benvenisty Nissim
ApplicationMany of the antineoplastic molecularly targeted agents, particularly those interfering with signal transduction (e.g., epidermal growth factor receptor inhibitors [EGFRi such as Cetuximab/Erbitux] and small molecule tyrosine kinase ...
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Benny Ofra
  Category Life Sciences and Biotechnology    Keywords Cancer, Glioblastoma, Precision Medicine, Early detection, Cancer mutations, DNA methylation, AI Current development stage For Pharmaceutical development: TRL4 - PoC&Safety of ...
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Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Background Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even ...
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Tabach Yuval
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...
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Barenholz Yechezkel
Background The release of targeted drugs is often achieved by attaching the drug load to a carrier through specific peptide sequences which are cleaved by proteases that are highly expressed at the desired location. Cathepsins proteases, ...
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Blum Galia
  Background Recent reports claim that about 38% of human breast cancers may contain sequences related to MMTV. Antibodies generated against mouse lymphoma cells that harbor the virus MMTV (mouse mammary tumor virus) were used to recognize ...
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Hochman Jacob
Prof. Levy-Lahad Ephrat – Director of the Medical Genetics Institute at Shaare Zedek Hospital, Jerusalem Background Breast cancer is the most common cancer among women. In >70% of cases with suspected hereditary, no mutations could be found ...
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Tabach Yuval
A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...
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Willner Itamar
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...
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Galski- Lorberboum Haya
Background Synthetic biology is the discipline of engineering application-driven biological functionalities that were not evolved by nature. Early breakthroughs of cell engineering, which were based on ectopic (over)expression of single sets of ...
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Nissim Lior
Category LifeSciences and BioTechnology    Keywords colorectal cancer, gut microbiota, personalized medicine Current development stage               For Pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is ...
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Ben-Neriah Yinon
  Category LifeSciences and Biotechnology    Keywords cancer, chemotherapy, prodrug Current development stage For Pharmaceutical development: TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models Choose ...
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Gibson Dan
Category LifeSciences and BioTechnology    Keywords Immunotherapy;  T cells, CAR T cells, NK cells  Current development stage: For Pharmaceutical development- TRL4 - PoC& Safety of candidate device or system is demonstrated in a ...
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Baniyash Michal
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
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Ben-Sasson Shmuel
  Category Life Sciences and Biotechnology    Keywords DNA sequencing, tumor detection, bioinformatic technology  ApplicationDNA methylation (5mC) is among the most promising biomarkers for detecting cancer and other diseases using ...
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Berman Benjamin
Category Life Sciences and Biotechnology    Keywords Oncology, Drug Development, EMTS   Overview The development of metastases in vital organs is the leading cause of death in cancer patients. Execution of the EMT (epithelial mesenchymal ...
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Shaul Yoav
Category Life Sciences and Biotechnology    Keywords Oncology, Breast Cancer, Splicing Modulation, Metabolic Diseases  Summary:Unbalanced alternative splicing of specific genes is present in several diseases including diabetes and cancer, ...
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Karni Rotem
Category Life Sciences and Biotechnology    Keywords Immunotherapy, Cancer  Overview:Human natural killer cells (NKs) are part of the innate immune system and can recognized CD48, which was found to be overexpressed by a variety of cancer ...
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Mandelboim Ofer
ApplicationIntegrins are transmembrane receptors that function as adhesion and signal transduction molecules, thus transducing information “outside-in” and “inside-out”. Diverse human pathologies involve integrin adhesion including inflammation, ...
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Gilon Chaim
  Highly sensitive, self formed and simple to fabricate nano junction devices changing resistance in the presence of minute concentration of volatile gases:   Background Detectors of volatile gas, including combustible gases, are essential ...
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Yerushalmi Roie