Projects related to 6-2015-4238

Results Found (19)
Technology NameBriefcaseLead Researcher
Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...
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Tirosh Oren
  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...
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Tsvelikhovsky Dmitry
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
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Ben-Sasson Shmuel
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
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Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
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Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Additional information will be provided upon request
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Domb Abraham
  Background Neuro-protective drugs products of all types protect the brain and peripheral nervous system neurons from degeneration and injury by promoting neuronal survival, proliferation and differentiation. These products can be used in the ...
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Tsvelikhovsky Dmitry
Background Agonists that bind well to the cannabinoid CB2 receptor and do not bind, or only bind weakly to the cannabinoid CB1 receptor are very promising therapeutic compounds for a wide range of disorders. CB1 agonists (such as the ...
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Mechoulam Raphael
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Categories: Life sciences and Biotechnology Technology Keywords: Drug Development, PPARD, Obesity, Glycogen Preserving, Lipid Metabolism, Wound Healing Development Stage: In silico, Identification of lead molecules, in vitro ...
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Goldblum Amiram
Category LifeSciences and BioTechnology    Keywords congestive heart failure, atrial fibrillation, cardiac steroids Current development stage For Pharmaceutical development: TRL4 - PoC&Safety of candidate device or system is ...
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Lichtstein David
  Category LifeSciences and Biotechnology    Keywords cancer, chemotherapy, prodrug Current development stage For Pharmaceutical development: TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models Choose ...
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Gibson Dan
 Background Quorum sensing takes place in biofilms where microbes such as bacteria and fungi are at close proximity to one another Inter species quorum sensing may affect microbes’ physiology and virulence properties, resulting in the ...
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Steinberg Doron
Background The invention brings a new modality of anti-bacterial treatment as a stand-alone therapy or combined with antibiotics The bacterial toxin MazF induces bacterial cell death by triggering downstream death pathways. The labile ...
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Engelberg-Kulka Hanna
  The technology enables an affordable and easily deployable method for detection of water/soil contamination, and/or rapid detection of viruses in humans and animals. The  method  employs the extension of the isothermal rolling circle ...
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Willner Itamar
  Highly sensitive, self formed and simple to fabricate nano junction devices changing resistance in the presence of minute concentration of volatile gases:   Background Detectors of volatile gas, including combustible gases, are essential ...
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Yerushalmi Roie
Background Bacteria communicate and coordinate population behavior through the mechanism of quorum sensing (QS), which controls the expression of genes that affect a variety of bacterial processes. Cannabis, Cannabinoids and endo-cannabinoids ...
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Steinberg Doron
Nir-Paz Ran, Hadassah Medical Center Background The World Health Organization has announced antibiotic resistance is one of the biggest threats to global health, food security and development today. Up to 50% of infections in G7 countries may be ...
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Hazan Ronen