| Technology Name | Briefcase | Lead Researcher |
|---|---|---|
Background
Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ... More | Tirosh Oren | |
Background
Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ... More | Tsvelikhovsky Dmitry | |
Our Innovation
Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ... More | Ben-Sasson Shmuel | |
Background
Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds.
These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ... More | Tsvelikhovsky Dmitry | |
Background
As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models.
Our Innovation
A new approach to treat ... More | Reich Reuven | |
Background
Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ... More | Dzikowski Ron | |
Additional information will be provided upon request
More | Domb Abraham | |
Background
Neuro-protective drugs products of all types protect the brain and peripheral nervous system neurons from degeneration and injury by promoting neuronal survival, proliferation and differentiation. These products can be used in the ... More | Tsvelikhovsky Dmitry | |
Background
Agonists that bind well to the cannabinoid CB2 receptor and do not bind, or only bind weakly to the cannabinoid CB1 receptor are very promising therapeutic compounds for a wide range of disorders.
CB1 agonists (such as the ... More | Mechoulam Raphael | |
New Ti(IV) metal complexes of Salan-ligands for Cancer treatment with reduce side effects (No. 2497)
Background
Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents.
However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ... More | Tshuva Edit | |
Categories:
Life sciences and Biotechnology
Technology Keywords:
Drug Development, PPARD, Obesity, Glycogen Preserving, Lipid Metabolism, Wound Healing
Development Stage:
In silico, Identification of lead molecules, in vitro ... More | Goldblum Amiram | |
Category
LifeSciences and BioTechnology
Keywords
congestive heart failure, atrial fibrillation, cardiac steroids
Current development stage
For Pharmaceutical development: TRL4 - PoC&Safety of candidate device or system is ... More | Lichtstein David | |
Category
LifeSciences and Biotechnology
Keywords
cancer, chemotherapy, prodrug
Current development stage
For Pharmaceutical development: TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models
Choose ... More | Gibson Dan | |
Categories
Small molecules, anti-inflammatory treatment
Development Stage
In-vivo proof of concept
Patent Status
Patent application filed
Market
Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ... More | Weinstock-Rosin Marta | |
Background
A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein, such as dystrophin in Duchenne muscular dystrophy. Nonsense mutations caused by premature stop codon, are treated ... More | Karni Rotem | |
Additional information will be provided upon request
More | Domb Abraham | |
Additional information will be provided upon request
More | Domb Abraham | |
Background
Toll-like receptors (TLRs) have been implicated in several autoimmune and inflammatory diseases, including cancer, diabetes, cardiovascular disease, atherosclerosis, Alzheimer’s disease, and chronic neuropathic pain.
Currently, ... More | Goldblum Amiram | |
Background
Age Related Macular Degeneration (AMD) is the leading cause of blindness in elderlies in the western world and an increasingly growing problem. The global AMD and diabetic retinopathy treatment market is overwhelmingly dominated by ... More | Benny Ofra | |
Background
Non-alcoholic fatty liver disease (NAFLD) and associated diseases Non-alcoholic steatohepatitis (NASH), Cirrhosis, and Hepatocellular carcinoma (HCC) cost the US economy an estimated at $103 billion per year. Lipotoxicity is a major ... More | Tirosh Oren | |
Background
Obesity is the leading cause of death in America, and is associated with an increase in chronic diseases like, cardiovascular diseases, hypertension, and metabolic disease involving the liver as well as type 2 diabetes. A recent study ... More | Monsonego-Ornan Efrat |