| Technology Name | Briefcase | Lead Researcher |
|---|---|---|
Our Innovation
The finding by HUJI researchers uncovers a novel structure of an outer mitochondrial membrane [Fe-S] protein (mitoNEET) determined by X-ray crystallography (Fig 1)
MitoNEET is an outer mitochondrial membrane protein that ... More | Nechushtai Rachel | |
Categories
Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis
Development Stage
(1) In vivo tests in ... More | Gertler Arieh | |
Prof. Yaron Ilan, Department of Human Nutrition and Metabolism and Liver Unit Hadassah Hospital
Background
To date, there is no effective treatment of liver diseases with the related Hepatic-Encephalopathy symptoms. It is established that ... More | Avraham Yosefa | |
Our Innovation
Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ... More | Ben-Sasson Shmuel | |
Categories
Small molecules, anti-inflammatory treatment
Development Stage
In-vivo proof of concept
Patent Status
Patent application filed
Market
Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ... More | Weinstock-Rosin Marta | |
Background
Primary human hepatocytes are isolated from organs rejected from transplantation. Cells are expensive, show massive batch-to-batch variability and fail to proliferate in culture. Hepatocytes are routinely used by the pharmaceutical ... More | Nahmias Yaakov | |
Background
Hyperlipidemia is a widespread condition that affects as many as one-third of adults and an increasing number of children in developed countries. Its pathogenesis mechanisms are only partly understood.
The small non-coding microRNAs ... More | Soreq Hermona | |
Background
Non-alcoholic fatty liver disease (NAFLD) and associated diseases Non-alcoholic steatohepatitis (NASH), Cirrhosis, and Hepatocellular carcinoma (HCC) cost the US economy an estimated at $103 billion per year. Lipotoxicity is a major ... More | Tirosh Oren | |
Category
Life Sciences and Biotechnology
Keywords
Metabolic Syndrome, Transfer RNA fragments, Fatty liver disease, Diagnostics, Antisense oligonucleotide therapeutics, Biomarkers, Hepatic hyperlipidemia
Current development stage
For ... More | Soreq Hermona | |
Categories:
Life sciences and Biotechnology
Technology Keywords:
Drug Development, PPARD, Obesity, Glycogen Preserving, Lipid Metabolism, Wound Healing
Development Stage:
In silico, Identification of lead molecules, in vitro ... More | Goldblum Amiram | |
BackgroundAccording to the World Health Organization approximately 422 million people currently suffer from diabetes. Type-I diabetes patients are characterized by their pancreas β-cells dysfunction and thereby absence of insulin secretion. ... More | Willner Itamar |