Projects related to 6-2015-3107

Results Found (35)
Technology NameBriefcaseLead Researcher
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...
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Karni Rotem
Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...
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Hellman Asaf
  Background Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even ...
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Tabach Yuval
Background Hyperlipidemia is a widespread condition that affects as many as one-third of adults and an increasing number of children in developed countries. Its pathogenesis mechanisms are only partly understood. The small non-coding microRNAs ...
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Soreq Hermona
Background PCR using bisulfite-treated DNA as a template, which is  followed by next generation sequencing (NGS), has a major potential as a diagnostic tool, by identifying DNA derived from specific tissue based on cell type-specific methylation ...
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Dor Yuval
A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...
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Willner Itamar
Background The therapeutic activity of most anticancer drugs in clinical use is limited by their general toxicity to proliferating cells, including some normal cells. Although chemists continue to develop novel cytotoxic agents with unique ...
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Willner Itamar
  Category Life Sciences and Biotechnology    Keywords Metabolic Syndrome, Transfer RNA fragments, Fatty liver disease, Diagnostics, Antisense oligonucleotide therapeutics, Biomarkers, Hepatic hyperlipidemia Current development stage For ...
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Soreq Hermona
  Category LifeSciences and BioTechnology    Keywords epilepsy, rare disease, gene therapy Current development stage For pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal ...
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Aqeilan Rami
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
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Hellman Asaf
Background X-ray computed tomography (CT) instruments are among the most available, efficient and cost-effective imaging modalities in hospitals. The field of CT molecular imaging agents is emerging relying mainly on detection of gold and ...
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Blum Galia
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
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Nechushtai Rachel
  Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...
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Benvenisty Nissim
Dr. Sharon Merims, Hadassah Medical Center   Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...
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Benny Ofra
 Background Glioblastoma multiforme (GBM) is a common, very aggressive brain cancer with a dismal prognosis, affecting young and middle-age adults with no effective treatment. Former efforts to diagnose glioblastoma tumors and tailor personal ...
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Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
Background To date, clinical tests that assess the level of malignancies from patient biopsies rely almost inclusively on histological analysis for specific markers and morphological cues as well as on genetic data i.e mutation analysis. In ...
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Benny Ofra
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...
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Barenholz Yechezkel
Background The release of targeted drugs is often achieved by attaching the drug load to a carrier through specific peptide sequences which are cleaved by proteases that are highly expressed at the desired location. Cathepsins proteases, ...
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Blum Galia
  Background Recent reports claim that about 38% of human breast cancers may contain sequences related to MMTV. Antibodies generated against mouse lymphoma cells that harbor the virus MMTV (mouse mammary tumor virus) were used to recognize ...
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Hochman Jacob
Prof. Levy-Lahad Ephrat – Director of the Medical Genetics Institute at Shaare Zedek Hospital, Jerusalem Background Breast cancer is the most common cancer among women. In >70% of cases with suspected hereditary, no mutations could be found ...
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Tabach Yuval
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...
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Galski- Lorberboum Haya
  Cancer research is moving into the frontiers of how to assign the correct drug(s) to a given patient. Cancer clinicians and researchers commonly search for overexpression of oncogenic biomarkers to assign a targeted treatment, but lack ...
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Kravchenko-Balasha Nataly