Projects related to 7-2011-2622

Results Found (47)
Technology NameBriefcaseLead Researcher
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...
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Karni Rotem
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
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Hellman Asaf
Background Fluorescence guided surgery is currently clinically approved for non-specific fluorescent molecules (ICG and MB) and is therefore limited in terms of sensitivity and specificity. Most cancer targeted fluorescent molecules in ...
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Yavin Eylon
  Background        Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...
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Feldman Yuri
Background X-ray computed tomography (CT) instruments are among the most available, efficient and cost-effective imaging modalities in hospitals. The field of CT molecular imaging agents is emerging relying mainly on detection of gold and ...
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Blum Galia
Background Currently there are no molecules that can directly inhibit the activity of splicing factors. We created decoy oligonucleotides that directly bind and inhibit the splicing activity of splicing factors without affecting their ...
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Karni Rotem
    Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...
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Breuer Eli
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
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Nechushtai Rachel
  Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...
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Benvenisty Nissim
Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...
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Hellman Asaf
Dr. Sharon Merims, Hadassah Medical Center   Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...
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Benny Ofra
 Background Glioblastoma multiforme (GBM) is a common, very aggressive brain cancer with a dismal prognosis, affecting young and middle-age adults with no effective treatment. Former efforts to diagnose glioblastoma tumors and tailor personal ...
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Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
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Ben-Sasson Shmuel
  Background Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even ...
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Tabach Yuval
Keywords cell free DNA diagnosis, liquid biopsies, methylation patterns, histone modification Current development stage   TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro modelsApplication The existing sequence ...
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Friedman Nir
Background To date, clinical tests that assess the level of malignancies from patient biopsies rely almost inclusively on histological analysis for specific markers and morphological cues as well as on genetic data i.e mutation analysis. In ...
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Benny Ofra
Background Current preclinical and clinical data indicate that there is negligible release of drug from circulating liposomes. Once liposomes extravagate to extracellular tissue fluids, little is known of the processes determining drug release. ...
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Barenholz Yechezkel
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...
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Barenholz Yechezkel
      Our Innovation We found and patented that approved drugs enhance the expression of NKp30 ligand. The upregulation is persistent and does not affect cell viability. We suggest to use this new modality as a combination therapy to improve ...
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Tirosh Boaz
Background The release of targeted drugs is often achieved by attaching the drug load to a carrier through specific peptide sequences which are cleaved by proteases that are highly expressed at the desired location. Cathepsins proteases, ...
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Blum Galia
  Background Recent reports claim that about 38% of human breast cancers may contain sequences related to MMTV. Antibodies generated against mouse lymphoma cells that harbor the virus MMTV (mouse mammary tumor virus) were used to recognize ...
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Hochman Jacob
Prof. Levy-Lahad Ephrat – Director of the Medical Genetics Institute at Shaare Zedek Hospital, Jerusalem Background Breast cancer is the most common cancer among women. In >70% of cases with suspected hereditary, no mutations could be found ...
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Tabach Yuval
Once-daily, sustained-release Sirolimus delivery system Categories Oral Cavity, Oncology/Cancer, Sustained Release, Drug Delivery Development Stage Prototypes tested in vitro; pharmokinetic and pharmacodynamic testing in human volunteers ...
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Friedman Michael
A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...
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Willner Itamar
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Background We encapsulated the dual-purpose moiety (x-ray contrast agent and visual detection) in liposomes in order to provide a long residence time of the dye in the tumor site achieving increased accumulation and retention at the SLN. Our ...
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Golomb Gershon
Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...
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Galski- Lorberboum Haya