Projects related to 8-2006-198

Results Found (65)
Technology NameBriefcaseLead Researcher
  Background One of the largest families of receptors in the human genome is that of the 7 -ransmembrane receptor (7-TMR) superfamily, also known as G-protein coupled receptors (GPCRs), numbering approximately 2000. G-protein coupled receptors ...
More
Ben-Sasson Shmuel
  Categories Small molecules, anti-inflammatory treatment Development Stage In-vivo proof of concept Patent Status Patent application filed Market Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ...
More
Weinstock-Rosin Marta
Background Natural killer (NK) cells are innate effector lymphocytes that efficiently kill tumor cells without prior stimulation. NK are crucial first responders to tumor transformation and viral, bacterial, or fungal infections. They are also ...
More
Mandelboim Ofer
Category Life Sciences and Bio Technology    Keywords Iterative Stochastic Elimination (ISE), Ligands, TLRs Current development stage TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro ...
More
Goldblum Amiram
Wide range of disorders including inflammation, pain, neurological and neurodegenerative diseases, MS, cancer Categories Immunology, Inflammation, CNS, Cardiovascular, Small Molecule Development Stage Tested in head injury small animal ...
More
Mechoulam Raphael
  Background Mast cells (MCs) are a type of white blood cell active in the immune system. They are produced in the bone marrow and play a key role in the inflammatory process.  Additionally, they are the primary driver of allergic reactions, ...
More
Levi-Schaffer Francesca
  Background DNA mutations in mitochondrial proteins/enzymes (nuclear encoded) that may lead to disease are present in approximately 1 in 8,000 individuals. Any treatment for mitochondrial diseases must be capable of targeting and crossing the ...
More
Galski- Lorberboum Haya
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
More
Nechushtai Rachel
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
More
Ben-Sasson Shmuel
Background Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces Neuropeptides are potent CNS neuromodulators and have many ...
More
Domb Abraham
Keywords Anti-Aging, Vascular Endothelial Growth Factor Current development stage TRL3 - hypothesis testing and intial POC demonstrated in limited number of in-vitro modelsApplication With continuous increase in the elderly population, many ...
More
Keshet Eli
Fills the gap between crystallography and optical imaging    Background Information about macromolecules is encoded in their shape and the way they are assembled. X-ray scattering methods are important tools for investigating the structure and ...
More
Raviv Uri
Background Peptides are key players in a variety of physiological and pathological processes and play very important roles in modulating various cell functions. One of the most important challenges developing peptide drugs is the lack of ...
More
Gilon Chaim
Keywords Cell death, dopaminergic (DA) neurons, L-Dopa-induced dyskinesia (LID) Current development stage TRL3 - hypothesis testing and initial POC demonstrated in limited number of in-vitro models Application Parkinson’s Disease (PD) is a ...
More
Atlas Daphne
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...
More
Karni Rotem
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
More
Hellman Asaf
Background Fluorescence guided surgery is currently clinically approved for non-specific fluorescent molecules (ICG and MB) and is therefore limited in terms of sensitivity and specificity. Most cancer targeted fluorescent molecules in ...
More
Yavin Eylon
  Background        Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...
More
Feldman Yuri
  Category Life Sciences and Biotechnology    Keywords Cathespin, Molecular Imaging, Cancer, CT, Computed Tomography, Current development stage TRL3 - Hypothesis testing and initial POC demonstrated in-vivo Application X-ray computed ...
More
Blum Galia
  Categories Treatment of cancer, neurodegeneration and infectious diseases. Development Stage In vitro proof of concept; in vivo POC Patent Status PCT publication number : WO2016/142948Highlights A new technology to inhibit the activity ...
More
Karni Rotem
    Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...
More
Breuer Eli
  Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...
More
Benvenisty Nissim
Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...
More
Hellman Asaf
Dr. Sharon Merims, Hadassah Medical Center   Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...
More
Benny Ofra
 Background Glioblastoma multiforme (GBM) is a common, very aggressive brain cancer with a dismal prognosis, affecting young and middle-age adults with no effective treatment. Former efforts to diagnose glioblastoma tumors and tailor personal ...
More
Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
More
Reich Reuven
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
More
Ben-Sasson Shmuel
  Background Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even ...
More
Tabach Yuval