9740

Enhancing Oral Bioavailability of Cannabinoids

Friedman Michael, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research
Hoffman Amnon, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research

Category

Prolonged release oral tablets   

Keywords

Cannabinoids, Cannabis, tablets, oral administration

 

Application

In recent years, the medical use of cannabis and its derivatives has become widely accepted in the medical profession.  IN addition, policy changes throughout many countries now allow for cannabis to be prescribed for medicinal purposes. For reasons of patient compliance as well as to control the side effects, there is a rising need for an oral controlled release cannabinoid formulation. Cannabinoids, however, are not candidates for classical controlled release delivery systems, because the extremely lipophilic characteristics of THC and CBD limit their absorption along the intestine.

Our Innovation

We suggest a novel solid dosage form that enables the controlled release of cannabinoids by using gastro retentive tablets. These formulations are designed sit in the stomach for a prolonged period of time, allowing the release of their drug load in a continuous manner. Subsequently, the patient will retain prolonged active blood levels that lead to benefits such as:

  • Fewer side effects associated with the peaks and lows of IR formulations
  • Superior patient compliance

Opportunity

The proposed Gastro-Retentive Tablets are a platform technology relevant for various therapeutic indications. They offer the advantage of oral administration along with both a controlled and prolonged release of cannabinoids.

Contact for more information:

Mel Larrosa
VP Business Development Healthcare
+972-2-6586692