4576

VitaLunga: Novel Oral Drug-Candidate to Prevent Age-Related Degenerative Diseases

Ben-Sasson Shmuel, HUJI, School of Medicine - IMRIC, Developmental Biology and Cancer Research
Gross Einav, HUJI, School of Medicine - IMRIC, Biochemistry and Molecular Biology

 Category

Category

Life Sciences and Biotechnology   

Keywords

Mitophagy restoration, age-related diseases

Current development stage

Initial POC demonstrated

 

Application

  • Mitophagy is a mitochondrial-recycling cell mechanism which is vital, high-fidelity quality-control system. The mitophagy ensures perpetual removal of damaged intracellular organelles and their replacement by newly formed ones.
  • Significant decay in quality-control by autophagy, in general, and mitophagy, in particular, is a hallmark of aging tissues which results in the evolvement of senescence-associated morbidities such as Alzheimer's disease, Parkinson's disease, congestive heart failure, skeletal muscle weakness and more.

Our Innovation

A novel technology/concept will enable the restoration of mitophagy efficiency, thereby preventing the evolvement of age-related degenerative diseases.

  • Direct illustration of enhanced mitophagy by the lead agent.
  • Abrogates muscle-strength deterioration with age.
  • Extend life span of treated organisms.
  • Enabling mitophagy efficiency restoration

Preclinical Results  

  • In vivo experiment was conducted using imaging experiments in order to explore the potency of compounds as mitophagy-inducers.
  • Several compounds that induced mitophagy were successfully identified.
  • A subset of novel small-molecules, sharing distinct structural features are able to induce robust mitophagy in-vivo in suitable organism model.

Opportunity

  • Reduction of age-related morbidity.
  • Improving elderly population quality-of-life significantly, utilizing rationally-designed biological means.

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
+972-2-6586608