4548
VEGF Stimulation for Anti-Aging Treatment
Keshet Eli, HUJI, School of Medicine - IMRIC, Developmental Biology and Cancer Research
Grunewald Miriam , HUJI, School of Medicine - IMRIC
Grunewald Miriam , HUJI, School of Medicine - IMRIC
Background
With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue.
Attenuating deleterious age-related processes taking place in multiple organs is highly desirable.
Our Innovation
A novel method for attenuating and/or delaying age-related deterioration using an externally supplied molecule that stimulates one of the body's own physiological signal transduction pathways at a very low level.
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Beneficial effect on multiple organs
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Attenuate and/or delay development of adverse phenotypes that develop naturally in aging individuals
Applications for use:
Effective treatment for age-related symptoms or disorders such as osteoporosis, steatosis, hematopoietic disturbances, sarcopenia, etc.
Pre-clinical Results
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Initial analysis of well-known age-related processes taking place in multiple organs reveals a remarkable attenuation of these processes in mice. The natural signal transduction pathway has been stimulated at low level with no side-effects.
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The finding uncovers a compelling evidence for the beneficial effect of this treatment per the processes like: Attenuation of bone mass loss, decreasing subcutaneous fat loss, decreasing development of a fatty liver and pancreas (steatosis) and counteracting age-related hematopoietic imbalances.
Patent Status
Published WO2019/198084
