VEGF Stimulation for Anti-Aging Treatment

Keshet Eli, HUJI, School of Medicine - IMRIC, Developmental Biology and Cancer Research
Grunewald Miriam , HUJI, School of Medicine - IMRIC


With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue.

Attenuating deleterious age-related processes taking place in multiple organs is highly desirable.

Our Innovation

A novel method for attenuating and/or delaying age-related deterioration using an externally supplied molecule that stimulates one of the body's own physiological signal transduction pathways at a very low level.

  • Beneficial effect on multiple organs
  • Attenuate and/or delay development of adverse phenotypes that develop naturally in aging individuals

Applications for use:

Effective treatment for age-related symptoms or disorders such as osteoporosis, steatosis, hematopoietic disturbances, sarcopenia, etc. 


Pre-clinical Results

  • Initial analysis of well-known age-related processes taking place in multiple organs reveals a remarkable attenuation of these processes in mice. The natural signal transduction pathway has been stimulated at low level with no side-effects.
  • The finding uncovers a compelling evidence for the beneficial effect of this treatment per the processes like: Attenuation of bone mass loss, decreasing subcutaneous fat loss, decreasing development of a fatty liver and pancreas (steatosis) and counteracting age-related hematopoietic imbalances.
  • The native induction resulted in dramatic extension of the individuals' lifespan


Patent Status

Published US-2021-0154270-A1

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare