4484

A Method for Improvement of Protein Production in Mammalian Cells

Tirosh Boaz, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research

Background

There is a growing demand in the field of biological drugs for improved protein expression platforms. Consequently there is a need for affordable manufacturing methods.

Our Innovation

A new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells

A single protein (oncoKIT) which improves growth and resilience to stress.

Technology

Generating stable expression of oncoKIT in production cell lines.

Application

We suggest companies to engineer their cell line with a protein that endows cells with better growth and productivity.

Opportunity

We offer companies that have their own propriety cells to use this for improvement. The proposed method to enhance protein expression has broad range of applications in R&D and biomanufacturing. The method helps to reduce the production costs and simplify the downstream processes of purification.