Dental Varnish for Long-Term Sustained-Release Therapy

Friedman Michael, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research
Steinberg Doron, HUJI, Faculty of Dental Medicine, Institute of Dental Sciences


Coatings, Biomaterials, Polymers, Composites, Dental Care

Development Stage

Successful clinical trials – ready for commercialization

Patent Status



The oral drug delivery market, the largest segment of the drug delivery market, is a $35 billion industry expected to grow up to 10% per year


  • Novel dental coating that delivers therapeutics as needed ,over time in response to changes that are “sensed” in acidic/basic conditions in the oral cavity
  • Dental disorders occur when there are changes in oral hygiene, diet, medicaments or age
  • Application-targeted reagent is suitable for oral disorders such as: tooth decay, periodontal diseases, implantitis, halitosis, tooth whitening, hypersensitivity, cancer, fungal infection, and the repair and regeneration of bone, cartilage, tendon and ligament defects.

Our Innovation

The application is a pharmaceutical platform into which various types of drugs can be incorporated.

Key Features

  • Increases exposure time to medication, preventing infections even for procedures in the root canal
  • Enables sustained release treatment effective against bacteria, yeasts, viruses and fungi
  • Reduces amount of drugs required, thus minimizing side effects. These advantages result in better clinical improvement and better patient compliance.
  • Built-in pH sensor increases the rate of release of medication and delivers medication as required in response to changes in pH that occur in many pathological oral disorders such as infections, caries, inflammations, dry mouth, halitosis, and candidiasis.
  • Simple production process; straightforward scale-up

Development Milestones

Seeking industry cooperation for commercialization

The Opportunity

Additional applications for medicine in human or in animals

Patent Status

Granted US 10,843,013; Europe

Contact for more information:

Ilya Pittel