Novel Methods for Micro-Encapsulation by Non-Aqueous Sol-Gel Routes

Abu-Reziq Raed , HUJI, Faculty of Science, The Institute of Chemistry


  • Today, The main method employed for the synthesis of silica microcapsules is based on an emulsion/sol-gel approach. This approach has been applied successfully in the microencapsulation of hydrophobic materials.
  • The encapsulation of hydrolytically unstable ingredients cannot be achieved by the current microencapsulation methods as they rely on water-based emulsions.
  • There are many candidates of pharmaceutical, agricultural or cosmetic active components that are water-sensitive or air-sensitive. To enable their encapsulation in silica shells, non-aqueous sol-gel routes must be involved.

Our Innovation

The researchers developed a novel microencapsulation technology. The technology is based on oil-in-oil emulsification and non-aqueous sol-gel chemistry that enables the encapsulation of various hydrophilic and hydrophobic active materials. The technology make it possible to encapsulate water-sensitive or air-sensitive actives that previously couldn't  be encapsulated by any other microencapsulation methods.

  • Encapsulate very hydrophilic materials purely without the need to dilute them in water.
  • Overcome the stability limitation of water-sensitive actives.
  • Applied for other types of hydrophilic or hydrophobic active materials.
  • Can be used to prepare microcapsules that are composed of different types of metal oxide.


  • Silica microcapsules containing pure polyethylene glycol (PEG) or glycerol in their core was successfully demonstrated for the first time.
  • Different types of ionic liquids, deep eutectic solvents, highly water-soluble agricultural actives were also microencapsulated as well as Vitamin A and Cymoxanil.
  • Octyl Methoxy Cinnamate (OMC) was encapsulated by a method in which the hydrophobic OMC is emulsified in PEG and then a silica shell is formed around the OMC droplets.
  • Taxol, anti-cancer drug, was microencapsulated in a similar way.



  • Pharmaceutical industry
  • Agricultural industry
  • Cosmetic industry
  • Chemical industry
  • Biotechnology industry