Novel platform for Discovering Cancer-Protecting Proteins Using Comparative Genomics

Tabach Yuval, HUJI, School of Medicine - IMRIC, Developmental Biology and Cancer Research



  • Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even increase the life expectancy.
  • Many species independently developed cancer resistance mechanisms. Multiple animals, like bats or the naked mole rat, have molecular mechanisms encoded in their genomes, making them resistant to cancer.Learning from other species can be achieved by utilizing comparative genomics approaches. The genomic revolution characterized by technological advances and shrinking cost of all DNA sequencing and analysis opened the door for comparative genomics research enabling us to detect basic biological similarities and differences and evolutionary relationships  

Using comparative genomic approaches, our new framework will be able to screen hundreds of genomes and identify the sequences that confer cancer resistance activity in different animals. Our algorithm will then can be use for designing new proteins, with improved cancer resistance activities, that can be used as drugs.

Our Innovation

  • New platform for Developing cancer vaccines that rely on millions of years of cancer resistance evolution. After analyzing cancer resistance signature and immunity in dozens of organisms and study their mechanisms of action, we will apply it to human.
  • Deep analysis of comparative genomics
  • New method for mapping gene networks
  • Cutting edge algorithms for understanding the organisms' anti-cancer blueprint and applying it to health management.
  • Novel diagnostic markers for cancer


  • Detecting the variants and regions of the DNA that led to the resistance mechanisms. Picking the variants that would further fit the human.
  • The statistical method based on DNA comparison between thousands of species can predict whether a variant is useful, neutral or harmful for a specific genetic background.
  • Already surveyed 20,000 genes and identified 200 that should fully explain the heredity factor in breast cancer.


Fig.1: The discovery platform


Fig. 2: Uncovering the missing heredity in breast cancer



  • Diagnostic tools, treatment and development of novel vaccines for cancer patients and for people with high risk for developing cancer.
  • New and re-purposing drugs based on gene interaction
  • Accurate diagnostics
  • Can be used also as a tools for enhancement crops yield.

Contact for more information:

Mel Larrosa
VP Business Development Healthcare
Contact ME: