Anti-infectious coating for implants

Reches Meital, HUJI, Faculty of Science, The Institute of Chemistry

The global dental implants market is projected to reach USD 13.01 billion by 2023 from USD 9.50 billion in 2018, at a CAGR of 6.5%. The market is driven by the growth in the geriatric population and corresponding age-related dental diseases and by the rising prevalence of tooth decay and periodontal diseases in the overall population across the globe. The demand has created an increasing willingness to adopt dental cosmetic surgery and a rise in dental implants.

However, dental implants are susceptible to infection due to the attachment of bacteria. The bacteria adsorb to the area of the implant using a layer of proteins. The proteins accumulate and form an organized network of bacteria termed biofilm. The biofilm allows the bacteria to exchange nutrients and metabolites among themselves and therefore enables them to develop resistance towards antibiotics. Today, there is a high demand for a bacterial-resistant coating that will prevent infections.

Our invention
The researcher suggests tackling the dental implant infections by a novel peptide of six amino acids. The peptide forms a bi-functional coating. On one hand it prevents the adsorption of bacterial proteins and the development of biofilm, on the other hand it promotes the attachment of mammalian cells (osteoclast) on the implant.

The technology presents a new strategy to combat the unmet need of dental implant infections. The suggested peptide spontaneously forms a coating under mild conditions. This coating prevents adsorption of organic and/or bio-organic materials to a surface in biological fluids. Moreover, the peptide encourages attachment of mammalian cells to the surface.

Thus, this invention provides a method for prolonging the lifetime of an implant and for stimulating bone healing or absorption of an implant after implantation.

Patent Status

Published 3347369

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Keren-Or Amar
VP, Business Development, Healthcare
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