Indocyanine Green (ICG) Formulations for Ureteral and Rectal Surgery Imaging

Magdassi Shlomo, HUJI, Faculty of Science, The Institute of Chemistry
Eyal Sara, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research


Identification of critical anatomic and pathologic structures in real time, during minimal invasive procedures poses a major challenge to surgeons.  

Our Innovation

A new modality- Liposomal IndoCyanine Green (ICG), enables a real-time, non-invasive, radiation-free method, based on Near-Infrared (NIR) technology to visualize designated structures such as ureters, rectal tumor margins.


  • ICG is the only FDA and EMA approved NIR dye with excellent safety profile (>30yrs).
  • The ICG provides more than one hour of illumination in a single dose.
  • Near Infrared technology already integrated into robotic and advance laparoscopic systems - a benchmarked imaging system

Product Applications

The ICG is packed in liposomes with variables diameters; this enables marking of different organs so ICG can contribute in a verity of surgical procedures.

1. Ureteral indicator- in order to prevent iatrogenic ureteral injuries which are a serious complication of 10% of abdominal surgeries. The average cost of ureter repair is extremely high, reaching $50K per ureteral injury.

2. Rectal tumor indicator- in rectal resection procedure, our technology assists to localize and determine the resection borders of the tumors, thus allowing better results in complete tumor removal & preservation of sphincter function.

Development Stage

  • Ureteral indicator- Proof of concept study in mice model and Proof of concept study in porcine model in a real OR- set-up with a benchmarked imaging system.
  • Rectal tumor indicator- Proof of concept study in mice model in vivo.


Patent Status

Granted Israel 237210

Contact for more information:

Shani Bullock
VP, Business Development, Healthcare
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