Ultra-Sensitive Method for In-Vitro Biomarker Detection

Porath Danny, HUJI, Faculty of Science, The Institute of Chemistry
FRIEDLER Assaf, HUJI, Faculty of Science, The Institute of Chemistry


A highly sensitive method for detection of biomarkers, based on formation of nanoparticle-biomarker hybrids (dimers) in the presence of a selected analyte. The project aims to develop a simple and affordable detection modality for these dimers based on nanopores (Fig. 1)- nanometer size holes in a thin membrane. The nanoparticle-biomarker dimers are translocated trough nanopores, inducing a signature signal that is specific for a given dimer-biomarker conjugate. The method will allow quantifying the biomarkers/analyte concentrations in a large dynamic range with ultra-high sensitivity and specificity.





Contact for more information:

Ariela Markel
VP, Business Development, Healthcare