A Growth Factor-Based Formulation For Treating Aging Skin

Mitrani Eduardo, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences

Nature’s way to keep tissues healthy


Cosmetics,  Cosmoceuticals, Aging Skin

Development Stage

Completed in vitro experiments, ready to develop a dossier documenting safety, efficacy in humans and manufacturing details (EEC-6th/7th amendments).

Patent Status

Provisional Patent application covering overall underlying technology filed, additional patent should be filed on manufacturing process


  • Formulation to treat ageing skin based on the natural combination of factors present in young regenerating skin.
  • Ageing skin should be treated with natural factors normally produced by healthy skin in order to stimulate: cell growth, synthesis of extra-cellular matrix components and the maintenance of an appropriate blood supply.
  • A proprietary, simple method has been developed to synthesize in the laboratory a combination of the necessary factors to perform the following functions: 1. Stimulate keratinocyte and fibroblast proliferation. 2. Induce synthesis of extracellular matrix components such as collagen, fibronectin and elastin. 3. Induce additional blood supply (angiogenesis) to the treated area.
  • The technology allows for the inexpensive and large scale production of the relevant combination of skin's own natural growth factors.
  • Broad platform that will allow to expand the pipeline to other cosmoceutical applications in the future


Our Innovation (facts and advantages)

  • Treating aging skin with the natural combination of growth factors normally secreted by healthy regenerating skin –body language.
  • Only the natural factors secreted by normal skin should be capable to maintain and regenerate a healthy skin
  • Our formulation of factors has been proved to 1. Stimulate keratinocyte and fibroblast proliferation. 2. Induce synthesis of collagen. 3. Induce angiogenesis.


The opportunity

  • As people are living longer, we are obsessed with diminishing the visible signs of chronological and photo aging. One manifestation of this obsession is that cosmetics for aging boomers, reached an estimated $40 billion in sales in 2005 and is expected to grow every year.
  • There are too many products on the market aimed at treating aging skin. However most are based on poor scientific facts and lack objective proofs of activity. We address the issue of ageing from a scientifically point of view by taking into consideration how human skin cells talk to each other to control cell renewal and synthesis of tissue components such as collagen and elastin:  -body language-.


Development Milestones

  • To develop a dossier documenting safety and efficacy of the formulation in humans and develop manufacturing details (EEC - 6th/7th amendments).
  • Set up manufacturing facilities.
  • Start sales.

Contact for more information:

Mel Larrosa
VP Business Development Healthcare
Contact ME: