1996
Novel Compounds for the Treatment of Obesity and reducing Glucose Levels
Avraham Yosefa, HUJI, School of Medicine - IMRIC, School of Public Health
Katzhendler Z"L Jehoshua, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research
Berry Elliot, HUJI, School of Medicine - IMRIC, School of Public Health
Katzhendler Z"L Jehoshua, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research
Berry Elliot, HUJI, School of Medicine - IMRIC, School of Public Health
Yousef Najajreh, Al Quds University
Background
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A growing number of peoples worldwide are suffering from the health consequences of obesity.
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As for today, Only one drug is currently approved for long-treatment of obesity-the lipase inhibitor Xenical. Use of this product has been limited by side effects.
Our Innovation
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The patent is covering Novel Active Compounds –derivatives of fatty acids and amino acids which may regulate feeding and body weight.
- Compound X (the leading compound) and its derivatives represent novel compounds for the treatment of obesity which do not act on either CB1, TRPV1 or PPAR-α receptors (tested by MSD for receptor binding activity).
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The compounds present new mechanisms of action (via POMC, NPY or FAAH (Fatty Acid Amide Hydrolase) inhibition in relation to known compounds on the market: Xenical (Lipase inhibition), Reductil (NE-5HT re-uptake inhibitor) and Rimonobant (CB1 receptor antagonist) (removed recently from the market).
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Highlights
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Patent on new compounds which are small natural, organic molecules.
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The Compounds are made of natural products which may be given orally and act in a dose-dependent manner.
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Three (3) compounds improve also cognitive function as well 3 compounds reduced glucose level.
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No toxicity was found following in-vivo experiments in mice, detecting survival, neurological score and liver histopathology.
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There is a clear opportunity for an effective and well-tolerated anti-obesity drugs. Weight loss continued for 31 days after cessation of treatment and then leveled off.
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Non toxic.
Patent Status
Granted US 9,428,448