10898

Novel Activating Antibodies for Viral Treatment

Levi-Schaffer Francesca, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research

 

Various pathogens (bacteria and viruses as well) bind to specific cell adhesion molecule in order to inhibit the immune response and/or to infect the host cells. However,  upon binding and induction/activation, the cell adhesion molecule suppresses virus production by an SHP2-dependent process which involves also suppression of mTOR-mediated protein biosynthesis.

We propose our anti- cell adhesion molecule activating mAb as a broad antiviral therapy (including Covid-19) that will:

  • Bind the cell membrane cell adhesion molecule in various lung (i.e. endothelial, epithelial dendritic and other) cells and stimulate anti-viral activity in these lung cells expressing the  cell adhesion molecule .
  • Bind and mask cell surface and virus associated cell adhesion molecule and render the possibility of Covid-19 cell adhesion molecule homotypic interaction with host cell and the following infection less feasible.