Probiotic Bacteria to Prevent Dental Caries

Steinberg Doron, HUJI, Faculty of Dental Medicine, Institute of Dental Sciences



Life Sciences and Bio-Technology   


Dental Biofilm, Probiotics, tooth decay, bacterial metabolism, dental caries, veterinary market

Current development stage

General list: TRL4 Technology validated in lab   


Dental caries is one of the most prevalent oral diseases caused mainly by Streptococcus mutans (S. mutans), which adhere to dental surfaces using adhesion-like proteins. S. mutans accumulation as a dental biofilm is the result of the bacteria's self-adhesion mechanisms but is also highly dependent on dietary components.

According to the World Health Organization (WHO), Dental Caries is considered the 11th most prevalent disease globally. Around half of the world population is suffering from untreated tooth decay or other oral diseases related to harmful microorganisms. Oral health care demands are beyond the capacities of health care systems in most low-and middle-income countries, therefore there is a need for low cost and easy to apply solutions.


Probiotics consist of beneficial micro-organisms that stimulate health promoting flora, thus suppressing pathologic colonization and disease spread. Probiotics can be provided in various oral products, such as food, beverages and dietary supplements. As such they have great potential for the prevention of dental biofilm and subsequent dental caries.

Our Innovation

We propose a new specific strain of probiotics bacteria and agents as a natural and effective means to prevent the development of dental caries. Our results have a demonstrated a significant effect on preventing the development of dental biofilms and show a  subsequent decrease in the occurrence of dental caries. This effective probiotic strain can be added to dental products and foods (e.g. toothpaste, mouth wash, chewing gum, and other local sustained release technologies).


The proposed solution can be easily adopted by diverse populations worldwide, including low-and middle-income countries where there is no sufficient dental care and/or a lack of oral health awareness. The oral probiotic market size has a growing prediction of 4.5% CAGR between 2019-2024.

Additional target market: Animal feed probiotics. The market size was valued at over USD 3.25 billion in 2017 and is projected to reach USD 5.07 billion by 2022. The market is driven by a rising demand for nutrient-rich feed for animals.


Contact for more information:

Mel Larrosa
VP Business Development Healthcare