Background Peripheral Arterial Disease (PAD) is the narrowing of peripheral arteries. By age 60 approximately 15% of the China population will have PAD. The problem commonly affects the lower limbs. Lower limb PAD is often diagnosed in late ...

Our Innovation We developed an efficient strategy to induce the formation of the endonuclease YqcG within bacterial cells. Within minutes following induction, 99.98% of the cells lose their genetic information and become DNA-less cells ...

  Additional information will be provided upon request

  Additional information will be provided upon request

  Additional information will be provided upon request

  Additional information will be provided upon request

  Additional information will be provided upon request

Background With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue. Attenuating deleterious age-related processes taking place in multiple organs is highly desirable. Our ...

Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...

  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...

Background: Dental disorders occur when there are changes in oral hygiene, diet, medicaments or age. Our Innovation Novel dental coating that delivers therapeutics over time, as required, in response to sensed changes in acidic/basic conditions ...

  Background Many kinds of surfaces are notorious sources of infection. Eradication of bacteria immobilized as biofilms on these surfaces is a major biological problem. Prevention of the development of biofilms is of prime concern to ...

Once-daily, sustained-release Sirolimus delivery system Categories Oral Cavity, Oncology/Cancer, Sustained Release, Drug Delivery Development Stage Prototypes tested in vitro; pharmokinetic and pharmacodynamic testing in human volunteers ...

Background Agonists that bind well to the cannabinoid CB2 receptor and do not bind, or only bind weakly to the cannabinoid CB1 receptor are very promising therapeutic compounds for a wide range of disorders. CB1 agonists (such as the ...

Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...

  Background With advances in biotechnology, nasal drug delivery is increasingly becoming a more viable alternative to oral and injectable routes of administration for an increasing number of drugs, including peptides. Our Innovation Platform ...

 Background Quorum sensing takes place in biofilms where microbes such as bacteria and fungi are at close proximity to one another Inter species quorum sensing may affect microbes’ physiology and virulence properties, resulting in the ...

Highlights Prevention of IgE-mediated allergic reaction by blocking and clearing pollen allergens with oxidized cellulose via its polysaccharide binding domain. Mode of administration: inhalation, intranasal, ocular, topical and ...

  Background DNA mutations in mitochondrial proteins/enzymes (nuclear encoded) that may lead to disease are present in approximately 1 in 8,000 individuals. Any treatment for mitochondrial diseases must be capable of targeting and crossing the ...