Our Innovation   The finding by HUJI researchers uncovers a novel structure of an outer mitochondrial membrane [Fe-S] protein (mitoNEET) determined by X-ray crystallography (Fig 1)  MitoNEET is an outer mitochondrial membrane protein that ...

  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...

  Background        Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...

Background: Autism spectrum disorder (ASD) is one of the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as ...

  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...

  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...

Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...

Category Life Sciences and Bio-Technology     Keywords Bone,  Fracture, Accelerated healing, Barrier, Injectable Current development stage TRL4 - PoC&Safety of candidate device or system is demonstrated in a defined lab or animal ...

  Background Zinc and copper are essential metal-ions for numerous biological processes.  Their levels are tightly maintained in all body organs. Impairment of serum Zn2+ to Cu2+ ratio (ZCR) was found to correlate with many disease states, ...

Background Age Related Macular Degeneration (AMD) is the leading cause of blindness in elderlies in the western world and an increasingly growing problem. The global AMD and diabetic retinopathy treatment market is overwhelmingly dominated by ...

  Application Improved electrical connections between neurons and electronic devices for human-device improved interface and for research Highlights The ring-like Stable Protein 1 (SP1) is a homo-dodecamer with an outer diameter of 11nm and ...

  Background Implant devices are extensively used, but have a few limitations: Most implants remain in the body even after they finish their task Removal of implants is costly and requires an invasive procedure; only 20-30% are actually ...

Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...

Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...

Background The surface chemistry and topography of implants are very important to their design. This is because the interface between the implant and the human body will determine how well the implant would integrate in the desired tissue. ...

  Categories: Life Science & Biotechnology Technology Keywords: Formulation, drug delivery, increased bioavailability Development Stage: POC in animalOur Innovation The PNL formulation composed of GRAS materials enabling ...

Category LifeSciences and BioTechnology    Keywords Therapeutic Agents, Liposomes, Biochemistry, Doxorubicin, Sulfate, Alkyl Sulfonate, DoxilTM  Application Current preclinical and clinical data indicate that there is negligible release of ...

Employing phospholipid binding properties of blood-cells expressed α-Synuclein for disease detection Categories Parkinson’s Disease, Diagnostics, Peptide/Protein, α-Synuclein Development Stage Proof of concept demonstrated Patent Status PCT ...

    Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...

Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...