Background Peptides are key players in a variety of physiological and pathological processes and play very important roles in modulating various cell functions. One of the most important challenges developing peptide drugs is the lack of ...

Keywords cell free DNA diagnosis, liquid biopsies, methylation patterns, histone modification Current development stage   TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro modelsApplication The existing sequence ...

Background The standard MRI approach requires large magnetic fields, yielding bulky and expensive machines. Moreover, the inductive measurement is limited in terms of sensitivity and resolution. These downsides result in limited availability ...

Background Bacteria communicate and coordinate population behavior through the mechanism of quorum sensing (QS), which controls the expression of genes that affect a variety of bacterial processes. Cannabis, Cannabinoids and endo-cannabinoids ...

Background Clean intermittent catherization is a gold standard care for urinary incontinence patents. A self-insertion of a plastic tube needs to be done 3-5 times a day. This leads to very low compliance resulting in an urinary overflow and ...

Keywords Innovative carrier, Nasal administration, Delivery to brain, Treatment of pain, disorders in Parkinson's disease, Multiple Sclerosis, Alzheimer, Epilepsy and brain trauma Current development stage Tested in animal model for ...

  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...

Background Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces Neuropeptides are potent CNS neuromodulators and have many ...

Background Hyperlipidemia is a widespread condition that affects as many as one-third of adults and an increasing number of children in developed countries. Its pathogenesis mechanisms are only partly understood. The small non-coding microRNAs ...

 Background Toll-like receptors (TLRs) have been implicated in several autoimmune and inflammatory diseases, including cancer, diabetes, cardiovascular disease, atherosclerosis, Alzheimer’s disease, and chronic neuropathic pain. Currently, ...

Application Prolonged epileptic seizures may lead to the development of life threatening cerebral state of a persistent seizure, referred as Status epilepticus (SE). Oral administration of anti-convulsants antiepileptic drugs (AEDs) as well ...

 Background A bipolar disorder is a form of a depressive disease that characteristically involves cycles of depression and elation or mania. The disorder is often a chronic recurring condition deteriorating one’s quality of life. Valnoctamide ...

Background X-ray computed tomography (CT) instruments are among the most available, efficient and cost-effective imaging modalities in hospitals. The field of CT molecular imaging agents is emerging relying mainly on detection of gold and ...

  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...

Dr. Sharon Merims, Hadassah Medical Center   Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...

Background Natural killer (NK) cells are innate effector lymphocytes that efficiently kill tumor cells without prior stimulation. NK are crucial first responders to tumor transformation and viral, bacterial, or fungal infections. They are also ...

Background Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces Neuropeptides are potent CNS neuromodulators and have many ...

Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...

      Our Innovation We found and patented that approved drugs enhance the expression of NKp30 ligand. The upregulation is persistent and does not affect cell viability. We suggest to use this new modality as a combination therapy to improve ...

Our Innovation   The finding by HUJI researchers uncovers a novel structure of an outer mitochondrial membrane [Fe-S] protein (mitoNEET) determined by X-ray crystallography (Fig 1)  MitoNEET is an outer mitochondrial membrane protein that ...