Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293.  An essential milestone in the production ...

Nir-Paz Ran, Hadassah Medical Center Background The World Health Organization has announced antibiotic resistance is one of the biggest threats to global health, food security and development today. Up to 50% of infections in G7 countries may be ...

Background Degenerative diseases become prominent with progressive ageing and thus present the most urgent biomedical challenge facing developed countries to date. One of the most prevalent musculoskeletal diseases caused during aging ...

  Category LifeSciences and BioTechnology    Keywords Pain, Opioid receptor, Addiction, Opioid addiction, Narcotics, AnalgesiaApplication Severe, high-impact chronic pain affects 20 million people in the US annually, and presents a common, ...

  Background Current methods of tissue fixation leave much to be desired, essentially relying on technologies developed from the clothing and carpentry industries i.e. sutures, screws, and pins. Bioadhesives offer a less traumatic method of ...

  Background Neutrophils are potent effector cells in a wide number of infectious, inflammatory and cancerous conditions. Modulation of Neutrophil functions in these conditions may have significant therapeutic benefits and effects on disease ...

  Background Solid tumors are known to continually form hypoxic microenvironments because the proliferating tumor cells grow faster than they can attract blood vessels towards them. In hypoxic microenvironments, where there is a lack of oxygen, ...

Background To date, clinical tests that assess the level of malignancies from patient biopsies rely almost inclusively on histological analysis for specific markers and morphological cues as well as on genetic data i.e mutation analysis. In ...

  Cancer research is moving into the frontiers of how to assign the correct drug(s) to a given patient. Cancer clinicians and researchers commonly search for overexpression of oncogenic biomarkers to assign a targeted treatment, but lack ...

Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...

Background The physical size of protein drugs and their susceptibility to degradation are key determinates that make them more dependent on drug delivery technologies. However formulating protein delivery systems so that they maintain their ...

Background Synthetic biology is the discipline of engineering application-driven biological functionalities that were not evolved by nature. Early breakthroughs of cell engineering, which were based on ectopic (over)expression of single sets of ...

  https://elsc.huji.ac.il/faculty-staff/yosef-grodzinsky   Background Language disorders affect up to 5% of all children and account for close to 20% of children with disabilities who receive special education. Language disorders make ...

Background We encapsulated the dual-purpose moiety (x-ray contrast agent and visual detection) in liposomes in order to provide a long residence time of the dye in the tumor site achieving increased accumulation and retention at the SLN. Our ...

Background The ability to control the shape, size and crystalline state of CaCO3 is significant for several industries including: Powder additives- improved flow properties (spherical shape versus irregular) of ink material, rubber filler, and ...

Our innovation: Neuropathic pain- One of our distinctive results which we optimized recently identifies several compounds that we identified as having a potential protective role in neuropathic pain. We pursued this finding in collaboration with ...

  Category Metabolic diseases Keywords Abdominal obesity, obesity Current development stage Pharmaceutical development: TRL2  Hypothesis Formulated        Collaboration Opportunity Sponsored Research with an option to License Research ...

Background The therapeutic activity of most anticancer drugs in clinical use is limited by their general toxicity to proliferating cells, including some normal cells. Although chemists continue to develop novel cytotoxic agents with unique ...

A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...

  Category LifeSciences and BioTechnology    Keywords Immunotherapy, Neuro-Immunotherapy, T cells, Cancer, HNC, HCC, Infectious diseases Current development stage TRL3 - Hypothesis testing and initial POC is demonstrated in limited ...