Coatings for Dental and Orthopedic Implants

Mandler Daniel, HUJI, Faculty of Science, The Institute of Chemistry



Development Stage

First and second generation of successful prototype implants post animal testing. 

Positive comparison to commercial products under physiological conditions.

Current establishment of near-physiologic conditions for deposition for next generation of prototype.

Proof-of-concept stage for antibiotics and growth factors integration


Orthopedic and Dental Implants



  • Orthopedic and dental implants are often coated with synthetic hydroxyapatite, the primary inorganic constituent of skeletal and dental tissues, in order to allow for better osseointegration and reduce physiological rejection. The coated apatites form direct bonds with adjacent hard tissues.
  • Plasma coating is the most common commercial method of fabrication.  High processing temperatures and the related residual stresses render the coatings prone to failure and suffer from limited lifetime.
  • In addition, integration of antibiotics and growth factors are one of the current leading challenges for improving implant technology. Under plasma coating preparation conditions, this cannot be achieved.  There is also a limitation of coating non-line-of-site surfaces such as those in trabecular metals.


Our Innovation

An electrochemical deposition method of hydroxyapatite in near-physiological conditions (in terms of temperature and pH) on CP-Ti, Ti-6Al-4V and other metallic implant surfaces.  Parameters of thickness, composition, and microstructure of the deposit are controlled.  A stable, porous, bone-like morphology, integrated with antibiotics and growth factors can be produced.  We have proven enhancement of the substrate-coating bond strength, enhanced osseointegration, and increased lifetime, along with the ability to coat porous scaffolds.



  • Process temperature and pH close to physiological conditions.  Coat is inherently stable in-vivo due to low solubility in body fluids and low residual stresses.
  • Proven improvement of the substrate/coating bond strength
  • Coating of porous, geometrically complex surfaces and allowing for integration of antibodies and growth factors. 
  • Ability to load the coating with biomolecules, antibiotics, growth factors, ets. In situ.
  • Fabrication method not requiring high applied potentials or current densities
  • Thickness and other parameters control.
  • Use of available and low-cost equipment.

Development Milestones

Seeking investment in new company or industrial collaboration for the development.

Patent Status

Published WO 2018/042430

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
Contact ME:
All projects by:Mandler Daniel (4)