Researcher interests: The unifying theme of our group is discovery and design of advanced molecular intermediates able to serve as common platforms for synthesis of various, structurally related (proceeding from same key subunit) compounds – potential therapeutic agents and drug candidates. Unlike existing classic synthetic “target-directed” methods, our constructing methodology offers conceptually new perspective, enabling to deliver multiple targets via sequence of controlled, simple and atom economy reactions from a single common molecular unit; thus, providing simplified access to a wide variety of important classes of biologically active and structurally interesting molecules.Building upon the foundations of synthetic organic chemistry, the research program of our group invokes a broad interdisciplinary collaboration with other fields such as, medicinal chemistry, organometallic chemistry, biochemistry, pharmacology and medicine.
FACULTY / SCHOOL: School of Medicine - IMRIC

Selected Publications

david lankri, riva nataf, Dmitry Tsvelikhovsky, yana konovalov, yelena mostinski
proline promoted dehydroxylation of α ketols (2019)| Chemical Science| Read more
Adi Lahiani, david lankri, dikla haham, philip lazarovici, Dmitry Tsvelikhovsky
methylene cycloalkylacetate mca scaffold based compounds as novel neurotropic agents (2017)| ACS Chemical Neuroscience| Read more
david lankri, Dmitry Tsvelikhovsky, yelena mostinski
palladium catalyzed cascade assembly of tricyclic spiroethers from diene alcohol precursors (2017)| Journal of Organic Chemistry| Read more
gilad noy, Avi Priel, Rakesh Kumar, Dmitry Tsvelikhovsky, yelena mostinski
tricyclic spirolactones as modular trpv1 synthetic agonists (2017)| ACS Chemical Neuroscience| Read more
david lankri, ghassan albarghouti, mohamed mahameed, Dmitry Tsvelikhovsky
multifaceted α enaminone adaptable building block for synthesis of heterocyclic scaffolds through conceptually distinct 1 2 1 3 1 4 and c o bond forming annulations (2017)| Journal of Organic Chemistry| Read more
david lankri, Dmitry Tsvelikhovsky, yelena mostinski
transition metal catalyzed synthesis of spirolactones (2017)| Synthesis| Read more
ramesh kotikalapudi, riva nataf, Dmitry Tsvelikhovsky, viviana valerio, yelena mostinski
palladium catalyzed cyclization of free hydroxyalkenoic acids regio and chemoselective access to methylene lactones (2017)| Advanced Synthesis & Catalysis| Read more
david lankri, ghassan albarghouti, ramesh kotikalapudi, Dmitry Tsvelikhovsky, viviana valerio
cascade pd ii catalyzed wacker lactonization heck reaction rapid assembly of spiranoid lactones (2016)| ChemInform| Read more
ramesh kotikalapudi, Dmitry Tsvelikhovsky, viviana valerio, yelena mostinski
stereo and regioselective synthesis of tricyclic spirolactones by diastereoisomeric differentiation of a collective key precursor (2016)| ChemInform| Read more
ramesh kotikalapudi, Dmitry Tsvelikhovsky, viviana valerio, yelena mostinski
stereo and regioselective synthesis of tricyclic spirolactones by diastereoisomeric differentiation of a collective key precursor (2016)| Chemistry: A European Journal| Read more

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