Researcher interests: The molecular mechanisms governing ubiquitination and Ubl-conjugation to cellular proteins.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
an n terminal extension to uba5 adenylation domain boosts ufm1 activation isoform specific differences in ubiquitin like protein activation (2019)|
Journal of Molecular Biology|
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assays for dissecting the in vitro enzymatic activity of yeast ubc7 (2019)|
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a sub population of group a streptococcus elicits a population wide production of bacteriocins to establish dominance in the host (2018)|
Cell Host & Microbe|
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trans binding of ufm1 to uba5 stimulates uba5 homodimerization and atp binding (2018)|
The FASEB Journal|
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novel insights into the interaction of uba5 with ufm1 via a ufm1 interacting sequence (2017)|
Scientific Reports|
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the crystal structure and conformations of an unbranched mixed tri ubiquitin chain containing k48 and k63 linkages (2017)|
Journal of Molecular Biology|
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conformational locking of ufm1 upon binding to the ufm1 interacting sequence of uba5 (2017)|
bioRxiv|
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ubiquitylation dependent oligomerization regulates activity of nedd4 ligases (2017)|
The EMBO Journal|
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trans binding mechanism of ubiquitin like protein activation revealed by a uba5 ufm1 complex (2016)|
Cell Reports|
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the vps27 hrs stam vhs domain of the signal transducing adaptor molecule stam directs associated molecule with the sh3 domain of stam amsh specificity to longer ubiquitin chains and dictates the position of cleavage (2016)|
Journal of Biological Chemistry|
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distinct activation of an e2 ubiquitin conjugating enzyme by its cognate e3 ligases (2015)|
Proceedings of the National Academy of Sciences of the United States of America|
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