Researcher interests: Vav1, an oncogene and a signal transducer protein: the links between the signaling pathways within cells and the transforming processes that cause cancer.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Developmental Biology and Cancer Research
Selected Publications
vav1 mutations identified in human cancers give rise to different oncogenic phenotypes (2018)|
Oncogenesis|
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po 196 vav1 and mutant k ras synergize in pancreatic ductal adenocarcinoma development lessons from mouse models (2018)|
Poster Presentation: Tumour Biology|
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po 135 analysis of the transforming activity of human cancer identified vav1 mutants prove its classification as an oncogene (2018)|
Poster Presentation: Cancer Cell Biology|
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vav1 a dr jekyll and mr hyde protein good for the hematopoietic system bad for cancer (2015)|
Oncotarget|
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mutations of c cbl in myeloid malignancies (2015)|
Oncotarget|
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mutation of vav1 adaptor region reveals a new oncogenic activation (2015)|
Oncotarget|
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vav1 promotes lung cancer growth by instigating tumor microenvironment cross talk via growth factor secretion (2014)|
Oncotarget|
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gtp exchange factor vav regulates guided cell migration by coupling guidance receptor signalling to local rac activation (2013)|
Journal of Cell Science|
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vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer (2013)|
PLOS ONE|
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276 vav1 the oncogenic switch (2012)|
European Journal of Cancer|
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human vav1 expression in hematopoietic and cancer cell lines is regulated by c myb and by cpg methylation (2012)|
PLOS ONE|
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