Retired
Researcher interests: biological damage and the roles played by radical and non-radical species including oxygen-derived (ROS) and nitrogen-derived (RNS) reactive species, redox-active catalytic metals, and chelating agents. Natural and synthetic antioxidants, and the mechanisms underlying their antioxidative and pro-oxidative effects. Cyclic stable nitroxide radicals, SOD mimics, the chemistry of nitroxides, their reactions with paramagnetic species, the biological effects of nitroxides, the catalytic activity of nitroxides, the mechanism(s) of nitroxide effects in cell-free systems and in tissues.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Microbiology and Molecular Genetics
Selected Publications
direct observation of acyl nitroso compounds in aqueous solution and the kinetics of their reactions with amines thiols and hydroxamic acids (2018)|
Journal of Physical Chemistry A|
Read more
nitrogen dioxide reaction with nitroxide radical derived from hydroxamic acids the intermediacy of acyl nitroso and nitroxyl hno (2018)|
Journal of Physical Chemistry A|
Read more
mechanism of hrp catalyzed nitrite oxidation by h2o2 revisited effect of nitroxides on enzyme inactivation and its catalytic activity (2017)|
Free Radical Biology and Medicine|
Read more
nitroxides protect horseradish peroxidase from h2o2 induced inactivation and modulate its catalase like activity (2017)|
Biochimica et Biophysica Acta|
Read more
nitroxides catalytically inhibit nitrite oxidation and heme inactivation induced by h2o2 nitrite and metmyoglobin or methemoglobin (2016)|
Free Radical Biology and Medicine|
Read more
nitroxide radicals for the treatment of diseases of the respiratory tract (2016)|
|
Read more
cyclic nitroxide radicals attenuate inflammation and hyper responsiveness in a mouse model of allergic asthma (2015)|
Free Radical Biology and Medicine|
Read more
chapter eight oxidation mechanism of hydroxamic acids forming hno and no implications for biological activity (2015)|
Advances in Inorganic Chemistry|
Read more
oxidation mechanism of hydroxamic acids forming hno and no implications for biological activity (2015)|
|
Read more
