Researcher interests: Control of prokaryotic ribosomal gene expression. Cloning of the promoter and terminator regions of the ribosomal gene. Structure and control of ribosomal RNA genes in mycoplasma. Structure-function relationship and cellular factors in the control of rRNA gene expression. Structure of frelA operon, control of expression. Dissection of relA lA gene product: structure- function relationship. relA gene of B subtilis and Thermus thermophillus. Study of chromosomal addiction module of E. coli, programmed cell death in E. coli.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Developmental Biology and Cancer Research
Selected Publications
naturally occurring food toxicants favismproducing agents (2018)|
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hipa mediated antibiotic persistence via phosphorylation of the glutamyl trna synthetase (2013)|
Nature Communications|
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design synthesis and structure activity relationship of novel relacin analogs as inhibitors of rel proteins (2013)|
European Journal of Medicinal Chemistry|
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relacin a novel antibacterial agent targeting the stringent response (2012)|
PLOS Pathogens|
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compounds for treating bacterial infections (2011)|
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ppgpp analogues inhibit synthetase activity of rel proteins from gram negative and gram positive bacteria (2010)|
Bioorganic & Medicinal Chemistry|
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energetics of mazg unfolding in correlation with its structural features (2009)|
Journal of Molecular Biology|
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guanine nucleotide derivatives for treating bacterial infections (2009)|
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mazg a regulator of programmed cell death in escherichia coli (2006)|
Molecular Microbiology|
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buffering of stable rna promoter activity against dna relaxation requires a far upstream sequence (2004)|
Molecular Microbiology|
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