Researcher interests: Molecular mechanisms of antibody formation. Differentiation and malignant transformation of B lymphocytes. Cancer - genomic instability and genomic alterations in precancerous lesions and/or cancer. Rare diseases - the pathophysiology and natural course of patients with primary antibody deficiencies (PAD).
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Developmental Biology and Cancer Research
Selected Publications
1st french israeli international conference on b cells and therapeutic antibodies october 23 25 2011 jerusalem israel (2012)|
mAbs|
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preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the igvh alleles of a rheumatoid factor producing lymphoblastoid cell line (2011)|
Molecular Immunology|
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ongoing somatic hypermutation of the rearranged vh but not of the v lambda gene in ebv transformed rheumatoid factor producing lymphoblastoid cell line (2008)|
Molecular Immunology|
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cytotoxicity of nf κb inhibitors bay 11 7085 and caffeic acid phenethyl ester to ramos and other human b lymphoma cell lines (2007)|
Experimental Hematology|
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somatic mutations and activation induced cytidine deaminase aid expression in established rheumatoid factor producing lymphoblastoid cell line (2007)|
Molecular Immunology|
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tumor necrosis factor α and cd40l modulate cell surface morphology and induce aggregation in ramos burkitt s lymphoma cells (2006)|
Leukemia & Lymphoma|
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differential effects of tumor necrosis factor α and cd40l on nf κb inhibitory proteins iκbα β and e and on the induction of the jun amino terminal kinase pathway in ramos burkitt lymphoma cells (2005)|
European Cytokine Network|
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expression of novel alternatively spliced isoforms of the oct 1 transcription factor (1999)|
Biochimica et Biophysica Acta|
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somatic mutations in the ig variable region genes and expression of novel cmu germline transcripts in a b lymphoma cell line farage not producing ig polypeptide chains (1998)|
Leukemia & Lymphoma|
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