Researcher interests: The molecular basis for oncogenic transformation.
FACULTY / SCHOOL: Faculty of Science
Selected Publications
an activating mutation in erk causes hyperplastic tumors in a scribble mutant tissue in drosophila (2019)|
Genetics|
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isolation and characterization of intrinsically active mek independent mutants of mpk1 erk (2017)|
Methods of Molecular Biology|
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how do protein kinases take a selfie autophosphorylate (2016)|
Trends in Biochemical Sciences|
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variants of the yeast mapk mpk1 are fully functional independently of activation loop phosphorylation (2016)|
Molecular Biology of the Cell|
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p38β mitogen activated protein kinase modulates its own basal activity by autophosphorylation of the activating residue thr180 and the inhibitory residues thr241 and ser261 (2016)|
Molecular and Cellular Biology|
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tighter αc helix αl16 helix interactions seem to make p38α less prone to activation by autophosphorylation than hog1 (2016)|
Bioscience Reports|
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intrinsically active variants of erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of tey phosphorylation (2016)|
Molecular Biology of the Cell|
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the yeast hot1 transcription factor is critical for activating a single target gene stl1 (2015)|
Molecular Biology of the Cell|
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transmembrane signaling in saccharomyces cerevisiae as a model for signaling in metazoans state of the art after 25 years (2014)|
Cellular Signalling|
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the p38β mitogen activated protein kinase possesses an intrinsic autophosphorylation activity generated by a short region composed of the α g helix and mapk insert (2014)|
Journal of Biological Chemistry|
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def pocket in p38α facilitates substrate selectivity and mediates autophosphorylation (2013)|
Journal of Biological Chemistry|
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conformational bias imposed by source microseeds results in structural ambiguity (2011)|
Acta Crystallographica Section F-structural Biology and Crystallization Communications|
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active mutants of the tcr mediated p38α alternative activation site show changes in the phosphorylation lip and def site formation (2011)|
Journal of Molecular Biology|
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