Researcher interests: Biophysical studies of protein-protein interactions at the molecular level, and of the effects of mutations and post-translational modifications on these interactions; biophysical methods to identify binding sites in cancer-related proteins. “Chemical chaperones“: development of peptides and small molecules that assist in refolding of proteins whose misfolding lead to disease.
FACULTY / SCHOOL: Faculty of Science

Selected Publications

Abraham Rimon, Assaf FRIEDLER, Etana Padan, ramakanta mondal
cardiolipin is an optimal phospholipid for the assembly stability and proper functionality of the dimeric form of nhaa na h antiporter (2019)| Scientific Reports| Read more
brian bauer, daniel mayer, dmitry b veprintsev, eshita mutt, franziska zosel, fred f damberger, frederic h t allain, Assaf FRIEDLER, gebhard f x schertler, jorg standfuss, mamidi samarasimhareddy, martha e sommer, mattan hurevich, miki feldmueller, tilman flock, xavier deupi, ziva vuckovic
distinct g protein coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019)| Nature Communications| Read more
Assaf FRIEDLER, hadar amartely, Oded Livnah, Mario Lebendiker, orly avraham
publisher correction coupling multi angle light scattering to ion exchange chromatography iex mals for protein characterization (2019)| Scientific Reports| Read more
Assaf FRIEDLER, hadar amartely, mai shamir, Mario Lebendiker
characterization of protein oligomers by multi angle light scattering (2019)| Encyclopedia of Analytical Chemistry| Read more
anat iosubamir, fang bai, Assaf FRIEDLER, guy mayer, henribaptiste marjault, jose n onuchic, luhua song, ola karmi, patricia a jennings, rachel nechushtai, ron mittler, Sagi Tamir, yangsung sohn
the anti apoptotic proteins naf 1 and iaspp interact to drive apoptosis in cancer cells (2019)| Chemical Science| Read more
daniel mayer, dmitry veprintsev, Assaf FRIEDLER, mamidi samarasimhareddy, mattan hurevich, norman metanis
a targeted approach for the synthesis of multi phosphorylated peptides a tool for studying the role of phosphorylation patterns in proteins (2019)| Organic and Biomolecular Chemistry| Read more
Assaf FRIEDLER, hadar amartely, Oded Livnah, Mario Lebendiker, orly avraham
coupling multi angle light scattering to ion exchange chromatography iex mals for protein characterization (2018)| Scientific Reports| Read more
dana grunhaus, Assaf FRIEDLER, odelia shimshon, ofrah faust, Eylon Yavin
protein regulation by intrinsically disordered regions a role for subdomains in the idr of the hiv 1 rev protein (2018)| ChemBioChem| Read more
hiv 1 integrase derived peptides and compositions comprising them (2018)| | Read more
ana maria lowcalle, carol prives, chen katz, david tong, francesca garofalo, Assaf FRIEDLER, jazminesaskya n josephchowdhury, joshua h choe, oleg laptenko, yan zhu
wild type and cancer related p53 proteins are preferentially degraded by mdm2 as dimers rather than tetramers (2018)| Genes & Development| Read more
Abraham Rimon, Assaf FRIEDLER, manish dwivedi, Etana Padan
asp133 residue in nhaa na h antiporter is required for stability cation binding and transport (2018)| Journal of Molecular Biology| Read more
Assaf FRIEDLER, hadar amartely, moriah koler, Ady Vaknin, vered frank
dynamic clustering of the bacterial sensory kinase baes (2016)| PLOS ONE| Read more
hiv 1 integrase derived peptides and compositions (2015)| | Read more
einav amit, Assaf FRIEDLER, Abraham Loyter, Mario Lebendiker, michal maes, tsafi danieli
the disordered region of arabidopsis vip1 binds the agrobacterium vire2 protein outside its dna binding site (2014)| Protein Engineering Design & Selection| Read more
deborah e shalev, Assaf FRIEDLER, Chaim Gilon, koushik chandra, Abraham Loyter, r benny gerber, tapta kanchan roy
a tandem in situ peptide cyclization through trifluoroacetic acid cleavage (2014)| Angewandte Chemie| Read more
deborah e shalev, Assaf FRIEDLER, Chaim Gilon, koushik chandra, Abraham Loyter, r benny gerber, tapta kanchan roy
frontispiece a tandem in situ peptide cyclization through trifluoroacetic acid cleavage (2014)| Angewandte Chemie| Read more
Assaf FRIEDLER, hadar benyamini, Abraham Loyter, ofrah faust, Ronen Gabizon, Sivan Nir
structure activity relationship studies using peptide arrays the example of hiv 1 rev integrase interaction (2013)| MedChemComm| Read more
Aviad Levin, danny porath, dvir rotem, Assaf FRIEDLER, Zvi Hayouka, limor zemel, Abraham Loyter, Ronen Gabizon, Shlomit Guy
monitoring the hiv 1 integrase enzymatic activity using atomic force microscopy in a 2ltr system (2013)| Chemical Communications| Read more
peptides that inhibit hiv 1 integrase by blocking its protein protein interactions (2012)| FEBS Journal| Read more
Aviad Levin, deborah e shalev, Assaf FRIEDLER, Chaim Gilon, Zvi Hayouka, Abraham Loyter, mattan hurevich
a comparative study of backbone versus side chain peptide cyclization application for hiv 1 integrase inhibitors (2012)| Bioorganic & Medicinal Chemistry| Read more

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