Researcher interests: Our lab is focusing on the pathologic interactions between carcinoma cells and host micro-environment. It becomes increasingly clear that during tumor progression cancer cells of epithelial origin actively remodel the host stroma, and the stromal compartment in turn profoundly modifies the malignant potential of the tumor cells. Detailed understanding of the molecular events responsible for these phenomena is necessary for development of effective anticancer therapies, targeting pathological interplay between carcinomas and their microenvironment. In particular, we are interested in pursuing the following avenues of investigation:     1.  Mechanisms through which chronic inflammation contributes to cancer progression and resistance to therapy:   a. tumor-associated macrophages and their mode of action in malignancy.    b.   inflammatory bowel diseases (IBD) - a prototype of chronic inflammation leading to cancer development. Abnormal interactions between cellular / extracellular elements of the colon tissue and their role in inflammation-driven tumorigenesis.   c. role of inflammatory microenvironment in conferring aggressiveness and radio/chemotherapy resistance in pancreatic cancer.    d. modulation of clinical behavior of the tumor by chronic infection in head & neck cancer.  2.   Complex relationships between heparanase enzyme (critical determinant of tumor-host interactions) and heparan sulfate proteoglycans (heparanase substrate and at the same time regulator of its activity), as important biological mechanism of cancer progression.   3. Impact of obesity / diabetes on patho-biologic characteristics of malignant tumors in breast/pancreas and their response to treatment.  4.  Control of tumor-microenvironment crosstalk in hormonally regulated cancers (i.e., breast, prostate).  
FACULTY / SCHOOL: School of Medicine - IMRIC
Contact Business Development: Shani Bullock

Selected Publications

bernard van den berg, Michael Elkin, ganqi wang, johan van der vlag, marjolein garsen, ton rabelink
heparanase roles in cell survival extracellular matrix remodelling and the development of kidney disease (2017)| Nature Reviews Nephrology| Read more
adi binder gallimidi, Amichay Meirovitz, barak weizman, Michael Elkin, esther hermano, Israel Vlodavsky, jorn karhausen, martin gotte, Gabriel Nussbaum
syndecan 1 deficiency promotes tumor growth in a murine model of colitis induced colon carcinoma (2017)| PLOS ONE| Read more
asher castiel, dikla atias, Michael Elkin, leonid mittelman, leonid visochek, malka cohenarmon, shai izraeli, talia golan, tamar peretz
exclusive destruction of mitotic spindles in human cancer cells (2017)| Oncotarget| Read more
Amichay Meirovitz, amir sonnenblick, Michael Elkin, esther hermano, Rachel Goldberg, tamar hamburger, tamar peretz
heparanase augments insulin receptor signaling in breast carcinoma (2017)| Oncotarget| Read more
alan rapraeger, Michael Elkin, Israel Vlodavsky, neta ilan, ralph sanderson
heparanase regulation of cancer autophagy and inflammation new mechanisms and targets for therapy (2017)| FEBS Journal| Read more
Michael Elkin, ilanit boyango, Israel Vlodavsky, lilach gutterkapon, neta ilan, preeti singh, ralph sanderson
heparanase from basic research to therapeutic applications in cancer and inflammation (2016)| Drug Resistance Updates| Read more
angelique rops, benner, berden, Michael Elkin, henry dijkman, Israel Vlodavsky, jinping, johan van der vlag, marjolein garsen, toin van kuppevelt, ton rabelink
heparanase is essential for the development of acute experimental glomerulonephritis (2016)| American Journal of Pathology| Read more
adi binder gallimidi, alina maliutina, ariel rubinstein, brurya revach, Michael Elkin, Gabriel Nussbaum, raanan bulvik, stuart fischman
periodontal pathogens porphyromonas gingivalis and fusobacterium nucleatum promote tumor progression in an oral specific chemical carcinogenesis model (2015)| Oncotarget| Read more
Amichay Meirovitz, ariel rubinstein, atzmon, Michael Elkin, gil, hermano, jinping, Rachel Goldberg, van der vlag
role of heparanase driven inflammatory cascade in pathogenesis of diabetic nephropathy (2014)| Diabetes| Read more
ariel rubinstein, Michael Elkin, esther hermano, eyal zcharia, immanuel lerner, Israel Vlodavsky, Tzahi Neuman
heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice ()| Cellular and Molecular Life Sciences| Read more

Contact for more information:

Shani Bullock
VP, Business Development, Healthcare
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