Researcher interests: RNA sensors: novel regulators of gene expression. mRNA structure and function. Translational control of eukaryotic gene expression. Regulation of mRNA splicing and the role of the RNA-activated protein kinase PKR therein. Molecular biology of immunoregulation, especially control of human cytokine (IL-2, IFN, TNF) gene expression. The cellular immune response and its dysregulation during superantigen toxic shock. Molecular biology of T cell activation by superantigens.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections (2014)|
JAMA Network|
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Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock (2011)|
Plos Biology|
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ATOX BIO INC.
Atox Bio is focused on the discovery and development of therapeutics for the treatment of infectious and autoimmune diseases mediated by excessive T-cell response. Having developed novel immunomodulators that reduce autoimmune response, as well...
