Researcher interests: RNA sensors: novel regulators of gene expression. mRNA structure and function. Translational control of eukaryotic gene expression. Regulation of mRNA splicing and the role of the RNA-activated protein kinase PKR therein. Molecular biology of immunoregulation, especially control of human cytokine (IL-2, IFN, TNF) gene expression. The cellular immune response and its dysregulation during superantigen toxic shock. Molecular biology of T cell activation by superantigens.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
control of mrna splicing by noncoding intragenic rna elements that evoke a cellular stress response (2018)|
The International Journal of Biochemistry & Cell Biology|
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bacterial superantigen toxins cd28 and drug development (2018)|
Toxins|
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an ancient pseudoknot in tnf α pre mrna activates pkr inducing eif2α phosphorylation that potently enhances splicing (2017)|
Cell Reports|
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pkr activation and eif2α phosphorylation mediate human globin mrna splicing at spliceosome assembly (2017)|
Cell Research|
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bacterial superantigen toxins induce a lethal cytokine storm by enhancing b7 2 cd28 costimulatory receptor engagement a critical immune checkpoint (2017)|
Receptors and clinical investigation|
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superantigens hyperinduce inflammatory cytokines by enhancing the b7 2 cd28 costimulatory receptor interaction (2016)|
Proceedings of the National Academy of Sciences of the United States of America|
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ATOX BIO INC.
Atox Bio is focused on the discovery and development of therapeutics for the treatment of infectious and autoimmune diseases mediated by excessive T-cell response. Having developed novel immunomodulators that reduce autoimmune response, as well...
